Liver X receptor β controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue
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- Yifei Miao
- Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;
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- Wanfu Wu
- Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;
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- Yubing Dai
- Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;
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- Laure Maneix
- Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;
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- Bo Huang
- Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;
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- Margaret Warner
- Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;
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- Jan-Åke Gustafsson
- Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204;
説明
<jats:title>Significance</jats:title> <jats:p>Liver X receptors (LXRs) are nuclear receptors vital in controlling lipid and glucose metabolism through direct or indirect mechanisms. Here, we demonstrate for the first time, to our knowledge, that, in addition to changing the activity of classic brown adipose tissue, LXRs, especially LXRβ, are able to regulate the browning of white adipose tissue (WAT), activation of mitochondria, and increased energy expenditure. Deletion of LXRs removed their suppressive effect on thyrotropin releasing hormone expression in brain, thus activating the hypothalamic–pituitary–thyroid (HPT) axis and inducing the browning of WAT. Altogether, the data confirm the importance on LXRs in ameliorating obesity through a previously unidentified mechanism (i.e., increasing browning of WAT and energy dissipation).</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 112 (45), 14006-14011, 2015-10-26
Proceedings of the National Academy of Sciences