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- Jean-Claude Twizere
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Jean-Yves Springael
- Institut de Recherche en Biologie Humaine et Moléculaire, Université Libre de Bruxelles Campus Erasme, Brussels, Belgium;
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- Mathieu Boxus
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Arsène Burny
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Franck Dequiedt
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Jean-François Dewulf
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Julie Duchateau
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Daniel Portetelle
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Patrice Urbain
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Carine Van Lint
- Laboratoire de Virologie Moléculaire, Institut de Biologie et de Médecine Moléculaires (IBMM), Service de Chimie Biologique, Université Libre de Bruxelles, Gosselies, Belgium;
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- Patrick L. Green
- Department of Veterinary Biosciences and Molecular Virology Immunology and Department of Medical Genetics, Center for Retrovirus Research, Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH; and
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- Renaud Mahieux
- Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
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- Marc Parmentier
- Institut de Recherche en Biologie Humaine et Moléculaire, Université Libre de Bruxelles Campus Erasme, Brussels, Belgium;
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- Luc Willems
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
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- Richard Kettmann
- Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium;
説明
<jats:title>Abstract</jats:title><jats:p>Human T-cell leukemia virus type-1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and neurological syndromes. HTLV-1 encodes the oncoprotein Tax-1, which modulates viral and cellular gene expression leading to T-cell transformation. Guanine nucleotide–binding proteins (G proteins) and G protein–coupled receptors (GPCRs) constitute the largest family of membrane proteins known and are involved in the regulation of most biological functions. Here, we report an interaction between HTLV-1 Tax oncoprotein and the G-protein β subunit. Interestingly, though the G-protein β subunit inhibits Tax-mediated viral transcription, Tax-1 perturbs G-protein β subcellular localization. Functional evidence for these observations was obtained using conditional Tax-1–expressing transformed T-lymphocytes, where Tax expression correlated with activation of the SDF-1/CXCR4 axis. Our data indicated that HTLV-1 developed a strategy based on the activation of the SDF-1/CXCR4 axis in the infected cell; this could have tremendous implications for new therapeutic strategies.</jats:p>
収録刊行物
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- Blood
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Blood 109 (3), 1051-1060, 2006-09-21
American Society of Hematology
