Bone marrow stromal cell–derived exosomes as communicators in drug resistance in multiple myeloma cells
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- Jinheng Wang
- Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium;
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- An Hendrix
- Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium; and
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- Sophie Hernot
- Laboratory for In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussels, Brussel, Belgium
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- Miguel Lemaire
- Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium;
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- Elke De Bruyne
- Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium;
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- Els Van Valckenborgh
- Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium;
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- Tony Lahoutte
- Laboratory for In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussels, Brussel, Belgium
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- Olivier De Wever
- Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium; and
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- Karin Vanderkerken
- Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium;
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- Eline Menu
- Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium;
書誌事項
- 公開日
- 2014-07-24
- DOI
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- 10.1182/blood-2014-03-562439
- 公開者
- American Society of Hematology
この論文をさがす
説明
<jats:title>Key Points</jats:title> <jats:p>BMSCs and MM cells mutually communicate through exosomes, which carry selective cytokines. BMSC-derived exosomes favor MM cell proliferation, migration, and survival and induce drug resistance to bortezomib.</jats:p>
収録刊行物
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- Blood
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Blood 124 (4), 555-566, 2014-07-24
American Society of Hematology