The human tumor microbiome is composed of tumor type–specific intracellular bacteria
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- Deborah Nejman
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Ilana Livyatan
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Garold Fuks
- Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
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- Nancy Gavert
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Yaara Zwang
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Leore T. Geller
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Aviva Rotter-Maskowitz
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Roi Weiser
- Division of Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
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- Giuseppe Mallel
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Elinor Gigi
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Arnon Meltser
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Gavin M. Douglas
- Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
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- Iris Kamer
- Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel.
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- Vancheswaran Gopalakrishnan
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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- Tali Dadosh
- Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
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- Smadar Levin-Zaidman
- Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
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- Sofia Avnet
- Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
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- Tehila Atlan
- Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Israel.
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- Zachary A. Cooper
- Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD, USA.
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- Reetakshi Arora
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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- Alexandria P. Cogdill
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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- Md Abdul Wadud Khan
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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- Gabriel Ologun
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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- Yuval Bussi
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Adina Weinberger
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Maya Lotan-Pompan
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Ofra Golani
- Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
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- Gili Perry
- Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel.
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- Merav Rokah
- Department of Thoracic Surgery, Sheba Medical Center, Ramat Gan, Israel.
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- Keren Bahar-Shany
- Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel.
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- Elisa A. Rozeman
- Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
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- Christian U. Blank
- Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
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- Anat Ronai
- Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel.
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- Ron Shaoul
- Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel.
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- Amnon Amit
- Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
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- Tatiana Dorfman
- Division of General Surgery, Rambam Health Care Campus, Haifa, Israel.
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- Ran Kremer
- Department of Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel.
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- Zvi R. Cohen
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Sagi Harnof
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Tali Siegal
- Neuro-Oncology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
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- Einav Yehuda-Shnaidman
- Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel.
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- Einav Nili Gal-Yam
- Breast Oncology Institute, Sheba Medical Center, Ramat Gan, Israel.
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- Hagit Shapira
- Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel.
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- Nicola Baldini
- Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
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- Morgan G. I. Langille
- Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
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- Alon Ben-Nun
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Bella Kaufman
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Aviram Nissan
- Department of Surgical Oncology (Surgery C), Sheba Medical Center, Ramat Gan, Israel.
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- Talia Golan
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Maya Dadiani
- Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel.
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- Keren Levanon
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Jair Bar
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Shlomit Yust-Katz
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Iris Barshack
- Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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- Daniel S. Peeper
- Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
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- Dan J. Raz
- Division of Thoracic Surgery, City of Hope Medical Center, Duarte, CA, USA.
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- Eran Segal
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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- Jennifer A. Wargo
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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- Judith Sandbank
- Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel.
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- Noam Shental
- Department of Mathematics and Computer Science, The Open University of Israel, Ra’anana, Israel.
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- Ravid Straussman
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
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説明
<jats:title>Profiling tumor bacteria</jats:title> <jats:p> Bacteria are well-known residents in human tumors, but whether their presence is advantageous to the tumors or to the bacteria themselves has been unclear. As an initial step toward addressing this question, Nejman <jats:italic>et al.</jats:italic> produced an exhaustive catalog of the bacteria present in more than 1500 human tumors representing seven different tumor types (see the Perspective by Atreya and Turnbaugh). They found that the bacteria within tumors were localized within both cancer cells and immune cells and that the bacterial composition varied according to tumor type. Certain biologically plausible associations were identified. For example, breast cancer subtypes characterized by increased oxidative stress were enriched in bacteria that produce mycothiol, which can detoxify reactive oxygen species. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6494" page="973" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.aay9189">973</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6494" page="938" related-article-type="in-this-issue" vol="368" xlink:href="10.1126/science.abc1464">938</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 368 (6494), 973-980, 2020-05-29
American Association for the Advancement of Science (AAAS)