Synthetic as compared with natural vitamin E is preferentially excreted as α‐CEHC in human urine: studies using deuterated α‐tocopheryl acetates
書誌事項
- 公開日
- 1998-10-16
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1016/s0014-5793(98)01210-1
- 公開者
- Wiley
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説明
<jats:p>α‐CEHC (2,5,7,8‐tetramethyl‐2(2′‐carboxyethyl)‐6‐hydroxychroman) is a urinary vitamin E metabolite with a truncated phytyl tail. To test whether natural and synthetic vitamin E are similarly converted to α‐CEHC, 6 humans consumed 150 mg each <jats:italic>RRR</jats:italic>‐α‐[5‐(C<jats:sup>2</jats:sup>H<jats:sub>3</jats:sub>)]‐ and <jats:italic>all rac</jats:italic>‐α‐[5,7(C<jats:sup>2</jats:sup>H<jats:sub>3</jats:sub>)<jats:sub>2</jats:sub>]‐tocopheryl acetates (d<jats:sub>3</jats:sub> <jats:italic>RRR</jats:italic>‐α‐ and d<jats:sub>6</jats:sub> <jats:italic>all rac</jats:italic>‐α‐tocopheryl acetates, respectively). Plasma was collected at 0, 6, 12 and 24 h; urine (24 h) at 0, 1, 2, 3, 4 and 8 days. Following dosing, plasma was enriched with d<jats:sub>3</jats:sub> <jats:italic>RRR</jats:italic>‐α‐tocopherol, while urine was enriched with α‐CEHC derived from d<jats:sub>6</jats:sub> <jats:italic>all rac</jats:italic>‐α‐tocopherol. Thus, synthetic compared with natural vitamin E is preferentially metabolized to α‐CEHC and excreted.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 437 (1-2), 145-148, 1998-10-16
Wiley