Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
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- Elaine Monteiro Cardoso-Lopes
- Section of Plant Physiology and Biochemistry, Institute of Botany, Box 3005, 01061-970, São Paulo, SP, Brazil
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- James Andreas Maier
- Section of Plant Physiology and Biochemistry, Institute of Botany, Box 3005, 01061-970, São Paulo, SP, Brazil
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- Marcelo Rogério da Silva
- Section of Plant Physiology and Biochemistry, Institute of Botany, Box 3005, 01061-970, São Paulo, SP, Brazil
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- Luis Octávio Regasini
- Institute of Chemistry, São Paulo State University, Box 355, 14801-970, Araraquara, SP, Brazil
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- Simone Yasue Simote
- Institute of Chemistry, São Paulo State University, Box 355, 14801-970, Araraquara, SP, Brazil
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- Norberto Peporine Lopes
- Department of Chemistry and Physics, São Paulo University, 14040-903, Ribeirão Preto, SP, Brazil
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- José Rubens Pirani
- Department of Botany, Biosciences Institute, São Paulo University, Box 11.461, 05422-970, São, Paulo, SP, Brazil
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- Vanderlan da Silva Bolzani
- Institute of Chemistry, São Paulo State University, Box 355, 14801-970, Araraquara, SP, Brazil
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- Maria Cláudia Marx Young
- Section of Plant Physiology and Biochemistry, Institute of Botany, Box 3005, 01061-970, São Paulo, SP, Brazil
書誌事項
- 公開日
- 2010-12-13
- 権利情報
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- https://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.3390/molecules15129205
- 公開者
- MDPI AG
説明
<jats:p>Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC50 = 2.5 mM), similar to that of the reference compound galanthamine (IC50 = 1.7 mM). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.</jats:p>
収録刊行物
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- Molecules
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Molecules 15 (12), 9205-9213, 2010-12-13
MDPI AG