Synchronized stereocontrol of planar chirality by crystallization-induced asymmetric transformation

Nobuhiro Kanomata, Gou Mishima, Jun Onozato

doi:10.1016/j.tetlet.2008.11.021

Synchronized stereocontrol of planar chirality by crystallization-induced asymmetric transformation

DOI Web Site Web Site 被引用文献12件

書誌事項

公開日: 2009-01

権利情報

https://www.elsevier.com/tdm/userlicense/1.0/

DOI

10.1016/j.tetlet.2008.11.021

公開者: Elsevier BV

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説明

Abstract Synchronized stereocontrol of two planar-chiral units was accomplished by using crystallization-induced asymmetric transformation (CIAT) of cyclophane-type bridged bisnicotinate derivatives 5b and 7 . After screening various linkers, ( S )-2-amino-1-butanol and ( S )- tert -leucinol were found to be the most effective for CIAT of the corresponding bridged bisnicotinate 5b and 7 , respectively, whose diastereomeric ratio finally reached 97% and 88%, respectively.