α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

DOI Web Site 19 Citations
  • Mark R. Silvis
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Bridget T. Kreger
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Wen-Hui Lien
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Olga Klezovitch
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • G. Marianna Rudakova
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Fernando D. Camargo
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Dan M. Lantz
    Dermatopathology Northwest, 2330 130th Avenue NE, Bellevue, WA 98005, USA.
  • John T. Seykora
    Department of Dermatology, University of Pennsylvania Medical School, Philadelphia, PA 19101, USA.
  • Valeri Vasioukhin
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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Description

<jats:p>A cell-cell adhesion protein suppresses skin carcinoma development by attenuating the signaling of a transcriptional coactivator in the Hippo pathway.</jats:p>

Journal

  • Science Signaling

    Science Signaling 4 (174), ra33-, 2011-05-24

    American Association for the Advancement of Science (AAAS)

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