Apple Procyanidins Suppress Amyloid<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">β</mml:mi></mml:mrow></mml:math>-Protein Aggregation

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  • Toshihiko Toda
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
  • Tadahiro Sunagawa
    Asahi Breweries, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan
  • Tomomasa Kanda
    Asahi Breweries, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan
  • Motoyuki Tagashira
    Asahi Breweries, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan
  • Takuji Shirasawa
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
  • Takahiko Shimizu
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan

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<jats:p>Procyanidins (PCs) are major components of the apple polyphenols (APs). We previously reported that treatment with PC extended the mean lifespan of<jats:italic>Caenorhabditis elegans</jats:italic>(Sunagawa et al., 2011). In order to estimate the neuroprotective effects of PC, we investigated the antiaggregative activity of PC on amyloid<jats:italic>β</jats:italic>-protein (A<jats:italic>β</jats:italic>) aggregation, which is a pathological hallmark of Alzheimer's disease. We herein report that PC significantly suppressed A<jats:italic>β</jats:italic>42 aggregation and dissociated A<jats:italic>β</jats:italic>42 aggregates in a dose-dependent manner, indicating that PC is a potent suppressor of A<jats:italic>β</jats:italic>aggregation. Furthermore, PC significantly inhibited A<jats:italic>β</jats:italic>42 neurotoxicity and stimulated proliferation in PC-12 cells. These results suggested that the PC and AP acted as neuroprotective factors against toxic A<jats:italic>β</jats:italic>aggregates.</jats:p>

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