IL-25 Causes Apoptosis of IL-25R–Expressing Breast Cancer Cells Without Toxicity to Nonmalignant Cells
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- Saori Furuta
- Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA.
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- Yung-Ming Jeng
- Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA.
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- Longen Zhou
- Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA.
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- Lan Huang
- Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, CA 92697, USA.
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- Irene Kuhn
- Department of Cancer and DNA Damage Responses, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
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- Mina J. Bissell
- Department of Cancer and DNA Damage Responses, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
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- Wen-Hwa Lee
- Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA.
書誌事項
- 公開日
- 2011-04-13
- DOI
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- 10.1126/scitranslmed.3001374
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p>Normal mammary epithelial cells secrete an anticancer cytokine, IL-25, suggesting that IL-25 receptor signaling may be a therapeutic target for breast cancer.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 3 (78), 78ra31-, 2011-04-13
American Association for the Advancement of Science (AAAS)
