Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD
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- Anthony O. Awojoodu
- Department of Biomedical Engineering and
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- Philip M. Keegan
- Department of Biomedical Engineering and
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- Alicia R. Lane
- Department of Biology, Georgia Institute of Technology, Atlanta, GA; and
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- Yuying Zhang
- Department of Biomedical Engineering and
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- Kevin R. Lynch
- Department of Pharmacology, The University of Virginia, Charlottesville, VA
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- Manu O. Platt
- Department of Biomedical Engineering and
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- Edward A. Botchwey
- Department of Biomedical Engineering and
書誌事項
- 公開日
- 2014-09-18
- DOI
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- 10.1182/blood-2014-01-543652
- 公開者
- American Society of Hematology
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説明
<jats:title>Key Points</jats:title><jats:p>Alterations in RBC membranes contribute to dysregulated sphingolipid metabolism in sickle cell disease (SCD). Increased RBC-derived MP production enhances monocyte adhesion and activation in SCD.</jats:p>
収録刊行物
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- Blood
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Blood 124 (12), 1941-1950, 2014-09-18
American Society of Hematology
