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- Pengfei Sui
- Department of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA.
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- Darin L. Wiesner
- Department of Pediatrics, University of Wisconsin–Madison, Madison, WI 53706, USA.
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- Jinhao Xu
- Department of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA.
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- Yan Zhang
- Department of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA.
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- Jinwoo Lee
- Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
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- Steven Van Dyken
- Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
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- Amber Lashua
- Laboratory of Genetics, University of Wisconsin–Madison, Madison, WI 53706, USA.
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- Chuyue Yu
- Zhiyuan College, Shanghai JiaoTong University, Shanghai, China.
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- Bruce S. Klein
- Department of Pediatrics, University of Wisconsin–Madison, Madison, WI 53706, USA.
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- Richard M. Locksley
- Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
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- Gail Deutsch
- Department of Laboratories, Seattle Children’s Hospital, University of Washington, Seattle, WA 98105, USA.
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- Xin Sun
- Department of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA.
書誌事項
- 公開日
- 2018-06-08
- DOI
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- 10.1126/science.aan8546
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Finding a role for PNECs in asthma</jats:title> <jats:p> Pulmonary neuroendocrine cells (PNECs) are a rare cell type located in airway and alveolar epithelia and are often in contact with sensory nerve fibers. They have a wide phylogenic distribution and are found even in the relatively primitive lungs of amphibia and reptiles, suggesting a critical function. Sui <jats:italic>et al.</jats:italic> found that mice lacking PNECs have suppressed type 2 (allergic) immune responses. PNECs were observed in close proximity to group 2 innate lymphoid cells (ILC2s) around airway branch points. The PNECs enhanced ILC2 activity by secreting CGRP (calcitonin gene-related peptide). They also induced goblet-cell hyperplasia via the neurotransmitter GABA (γ-aminobutyric acid). Interestingly, human asthma patients were found to have increased PNEC numbers, suggesting a potential therapeutic target for the treatment of asthma. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aan8546">eaan8546</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 360 (6393), eaan8546-, 2018-06-08
American Association for the Advancement of Science (AAAS)