Polarization of cell growth in yeast II. The role of the cortical actin cytoskeleton

DOI PDF 被引用文献16件
  • David Pruyne
    Department of Molecular Biology and Genetics, 353 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
  • Anthony Bretscher
    Department of Molecular Biology and Genetics, 353 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA

書誌事項

公開日
2000-02-15
権利情報
  • http://www.biologists.com/user-licence-1-1/
DOI
  • 10.1242/jcs.113.4.571
公開者
The Company of Biologists

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説明

<jats:title>ABSTRACT</jats:title> <jats:p>The actin cytoskeleton provides the structural basis for cell polarity in Saccharomyces cerevisiaeas well as most other eukaryotes. In Part I of this two-part commentary, presented in the previous issue of Journal of Cell Science, we discussed the basis by which yeast establishes and maintains different states of polarity through Rho GTPases and cyclin-dependent protein kinase signaling. Here we discuss how, in response to those signals, the actin cytoskeleton guides growth of the yeast cell. A polarized array of actin cables at the cell cortex is the primary structural determinant of polarity. Motors such as class V myosins use this array to transport secretory vesicles, mRNA and organelles towards growth sites, where they are anchored by a cap of cytoskeletal and regulatory proteins. Cortical actin patches enhance and maintain this polarity, probably through endocytic recycling, which allows reuse of materials and prevents continued growth at old sites. The dynamic arrangement of targeting and recycling provides flexibility for the precise control of morphogenesis.</jats:p>

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