Synthesis of sequential polydepsipeptides utilizing a new approach for the synthesis of depsipeptides
書誌事項
- 公開日
- 2004-02-17
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/bip.20013
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Sequential polydepsipeptides were synthesized by the depsipeptide active ester method using a new approach for the direct synthesis of N‐protected depsipeptide free acids from hydroxy acids. The method uses synthesis of Boc‐didepsipeptides by reaction of free hydroxy acids with Boc‐amino acid <jats:italic>N</jats:italic>‐hydroxysuccinimide esters catalyzed by 4‐dimethylaminopyridine and chain elongation of the free depsipeptides by the reaction with Boc‐amino acid <jats:italic>N</jats:italic>‐hydroxysuccinimide esters in an organic solvent system of acetonitrile‐tetrahydrofuran. The Boc‐depsipeptide free acids were activated as their <jats:italic>N</jats:italic>‐hydroxysuccinimide esters, which were polymerized after removal of the Boc‐protecting group. © 2004 Wiley Periodicals, Inc. Biopolymers, 2004</jats:p>
収録刊行物
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- Biopolymers
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Biopolymers 73 (6), 641-644, 2004-02-17
Wiley
