Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy
-
- Yue Sun
- Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
-
- Feng Ding
- Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
-
- Zhixuan Zhou
- Department of Chemistry, University of Utah, Salt Lake City, UT 84112;
-
- Chonglu Li
- Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
-
- Maoping Pu
- Institute of Organic Chemistry, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany;
-
- Yuling Xu
- Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
-
- Yibei Zhan
- School of Chemistry and Chemical Engineering, Hubei Polytechnic University, Huangshi 435003, China
-
- Xiaoju Lu
- School of Chemistry and Chemical Engineering, Hubei Polytechnic University, Huangshi 435003, China
-
- Haibing Li
- Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
-
- Guangfu Yang
- Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
-
- Yao Sun
- Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
-
- Peter J. Stang
- Department of Chemistry, University of Utah, Salt Lake City, UT 84112;
説明
<jats:title>Significance</jats:title> <jats:p>The biomedical applications of fluorescent anticancer agents in the first near-IR region (NIR-I) have been hampered by problems of photostability, autofluorescence, and limited penetration depth in biological tissues. To shift the fluorescence theranostic region from the NIR-I to the longer-wavelength region for accurate cancer diagnosis and treatment, Pt(II) metallacycle-based fluorescent nanoprobe 1 with fluorescence emission in the NIR-II region is designed. In vitro and in vivo studies demonstrate that 1 has good photostability and the ability to efficiently inhibit the growth of tumor with minimal side effects. It also improves the fluorescent imaging quality and signal-to-noise ratio for cancer theranostics. This study provides an opportunity for further design of NIR-II theranostic anticancer agents for future biomedical applications.</jats:p>
収録刊行物
-
- Proceedings of the National Academy of Sciences
-
Proceedings of the National Academy of Sciences 116 (6), 1968-1973, 2019-01-22
Proceedings of the National Academy of Sciences
