書誌事項
- 公開日
- 2013-11-21
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/all.12270
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>There is a growing desire to explain the worldwide rise in the prevalence of atopic dermatitis (<jats:styled-content style="fixed-case">AD</jats:styled-content>). Trend data on the burden of <jats:styled-content style="fixed-case">AD</jats:styled-content> suggest that the picture in the developing world may soon resemble that of wealthier nations, where <jats:styled-content style="fixed-case">AD</jats:styled-content> affects over 20% of children. This, combined with significant variations in prevalence within countries, emphasizes the importance of environmental factors. Many hypotheses have been explored, from the modulation of immune priming by hygiene, gut microbiota diversity, and exposure to endotoxins through farm animals to the effects of pollution, climate, and diet. The discovery of the filaggrin skin barrier gene and its importance in <jats:styled-content style="fixed-case">AD</jats:styled-content> development and severity has brought the focus on gene–environment interactions and the identification of environmental factors that impact on skin barrier function. This article reviews our current understanding of the epidemiology of <jats:styled-content style="fixed-case">AD</jats:styled-content>, with an emphasis on the findings reported in the international literature over the last 5 years.</jats:p>
収録刊行物
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- Allergy
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Allergy 69 (1), 3-16, 2013-11-21
Wiley