Inflammation after Intracerebral Hemorrhage

Jian Wang, Sylvain Doré

doi:10.1038/sj.jcbfm.9600403

Inflammation after Intracerebral Hemorrhage

DOI Web Site Web Site 被引用文献11件

Jian Wang

Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
Sylvain Doré

Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA

書誌事項

公開日: 2007-05

権利情報

https://journals.sagepub.com/page/policies/text-and-data-mining-license

DOI

10.1038/sj.jcbfm.9600403

公開者: SAGE Publications

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CiNii Books

説明

<jats:p>Intracerebral hemorrhage (ICH) is a devastating clinical event without effective therapies. Increasing evidence suggests that inflammatory mechanisms are involved in the progression of ICH-induced brain injury. Inflammation is mediated by cellular components, such as leukocytes and microglia, and molecular components, including prostaglandins, chemokines, cytokines, extracellular proteases, and reactive oxygen species. Better understanding of the role of the ICH-induced inflammatory response and its potential for modulation might have profound implications for patient treatment. In this review, a summary of the available literature on the inflammatory responses after ICH is presented along with discussion of some of the emerging opportunities for potential therapeutic strategies. In the near future, additional strategies that target inflammation could offer exciting new promise in the therapeutic approach to ICH.</jats:p>