Chromosome Condensation May Enhance X-Ray-Related Cell Lethality in a Temperature-Sensitive Mutant (tsBN2) of Baby Hamster Kidney Cells (BHK21)

DOI PubMed 被引用文献1件

書誌事項

公開日
1987-03
DOI
  • 10.2307/3577041
公開者
JSTOR

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説明

In the tsBN2 cell line, which has a temperature-sensitive defect in the regulatory mechanism for chromosome condensation, the lethal effect of X rays was enhanced by incubating the cells at a nonpermissive temperature (40 degrees C) following X irradiation. This enhancement was suppressed in the presence of cycloheximide, which inhibits induction of premature chromosome condensation. The findings obtained in the case of delayed incubation at 40 degrees C and in synchronized cells indicate that X-ray-related potentially lethal damage, which can be expressed by chromosome condensation, is produced in the cells at any stage of the cell cycle, but it is repairable for all cells except those at around the late G2-M phase, where chromosome condensation occurs at a permissive temperature (33.5 degrees C). These observations suggest that the high sensitivity of late G2-M cells to X rays is caused by the events associated with chromosome condensation.

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詳細情報 詳細情報について

  • CRID
    1363670319205787008
  • DOI
    10.2307/3577041
  • ISSN
    00337587
    http://id.crossref.org/issn/00337587
  • PubMed
    3562784
  • データソース種別
    • Crossref
    • OpenAIRE

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