Nephropathy in Sucrose-fed Rats: Electron and Light Microscopic Studies

E Rosenmann, A Teitelbaum, A M Cohen

doi:10.2337/diab.20.12.803

Nephropathy in Sucrose-fed Rats: Electron and Light Microscopic Studies

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E Rosenmann

Diabetic Unit and the Department of Pathology, Hebrew University-Hadassah Medical School Jerusalem, Israel
A Teitelbaum

Diabetic Unit and the Department of Pathology, Hebrew University-Hadassah Medical School Jerusalem, Israel
A M Cohen

Diabetic Unit and the Department of Pathology, Hebrew University-Hadassah Medical School Jerusalem, Israel

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説明

<jats:p>Diffuse intercapillary glomerulosclerosis and exudative glomerulosclerosis were produced in rats fed high-sucrose diet for periods of nine to eighteen months. These lesions were observed by light and electron miscroscopy. Impairment of glucose tolerance was observed in the sucrose-fed animals and marked proteinuria developed in the course of long-term sucrose feeding. Such lesions did not develop in a control group of age-matched fed high-starch diets.</jats:p>