Nephropathy in Sucrose-fed Rats: Electron and Light Microscopic Studies

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  • E Rosenmann
    Diabetic Unit and the Department of Pathology, Hebrew University-Hadassah Medical School Jerusalem, Israel
  • A Teitelbaum
    Diabetic Unit and the Department of Pathology, Hebrew University-Hadassah Medical School Jerusalem, Israel
  • A M Cohen
    Diabetic Unit and the Department of Pathology, Hebrew University-Hadassah Medical School Jerusalem, Israel

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Description

<jats:p>Diffuse intercapillary glomerulosclerosis and exudative glomerulosclerosis were produced in rats fed high-sucrose diet for periods of nine to eighteen months. These lesions were observed by light and electron miscroscopy. Impairment of glucose tolerance was observed in the sucrose-fed animals and marked proteinuria developed in the course of long-term sucrose feeding. Such lesions did not develop in a control group of age-matched fed high-starch diets.</jats:p>

Journal

  • Diabetes

    Diabetes 20 (12), 803-810, 1971-12-01

    American Diabetes Association

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