The Origins of Genome Complexity

DOI Web Site 被引用文献20件
  • Michael Lynch
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • John S. Conery
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.

書誌事項

公開日
2003-11-21
DOI
  • 10.1126/science.1089370
公開者
American Association for the Advancement of Science (AAAS)

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<jats:p>Complete genomic sequences from diverse phylogenetic lineages reveal notable increases in genome complexity from prokaryotes to multicellular eukaryotes. The changes include gradual increases in gene number, resulting from the retention of duplicate genes, and more abrupt increases in the abundance of spliceosomal introns and mobile genetic elements. We argue that many of these modifications emerged passively in response to the long-term population-size reductions that accompanied increases in organism size. According to this model, much of the restructuring of eukaryotic genomes was initiated by nonadaptive processes, and this in turn provided novel substrates for the secondary evolution of phenotypic complexity by natural selection. The enormous long-term effective population sizes of prokaryotes may impose a substantial barrier to the evolution of complex genomes and morphologies.</jats:p>

収録刊行物

  • Science

    Science 302 (5649), 1401-1404, 2003-11-21

    American Association for the Advancement of Science (AAAS)

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