Injectable Hydrogels for Cardiac Tissue Engineering

DOI Web Site Web Site 2 Citations
  • Brisa Peña
    Cardiovascular Institute School of Medicine Division of Cardiology University of Colorado Denver Anschutz Medical Campus 12700 E.19th Avenue, Bldg. P15 Aurora CO 80045 USA
  • Melissa Laughter
    Bioengineering Department University of Colorado Denver Anschutz Medical Campus Bioscience 2 1270 E. Montview Avenue, Suite 100 Aurora CO 80045 USA
  • Susan Jett
    Cardiovascular Institute School of Medicine Division of Cardiology University of Colorado Denver Anschutz Medical Campus 12700 E.19th Avenue, Bldg. P15 Aurora CO 80045 USA
  • Teisha J. Rowland
    Cardiovascular Institute School of Medicine Division of Cardiology University of Colorado Denver Anschutz Medical Campus 12700 E.19th Avenue, Bldg. P15 Aurora CO 80045 USA
  • Matthew R. G. Taylor
    Cardiovascular Institute School of Medicine Division of Cardiology University of Colorado Denver Anschutz Medical Campus 12700 E.19th Avenue, Bldg. P15 Aurora CO 80045 USA
  • Luisa Mestroni
    Cardiovascular Institute School of Medicine Division of Cardiology University of Colorado Denver Anschutz Medical Campus 12700 E.19th Avenue, Bldg. P15 Aurora CO 80045 USA
  • Daewon Park
    Bioengineering Department University of Colorado Denver Anschutz Medical Campus Bioscience 2 1270 E. Montview Avenue, Suite 100 Aurora CO 80045 USA

Search this article

Description

<jats:title>Abstract</jats:title><jats:p>In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio‐protective molecules, and improve cell‐based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise as a minimally invasive therapeutic approach. Moreover, injectable acellular alginate‐based hydrogels have been tested clinically in patients with myocardial infarction (MI) and show preservation of the left ventricular (LV) indices and left ventricular ejection fraction (LVEF). This review provides an overview of recent developments that have occurred in the design and engineering of various injectable hydrogel systems for cardiac tissue engineering efforts, including a comparison of natural versus synthetic systems with emphasis on the ideal characteristics for biomimetic cardiac materials.</jats:p>

Journal

Citations (2)*help

See more

Report a problem

Back to top