Increased serum concentration of carbohydrate-deficient transferrin in patients with combined pancreas and kidney transplantation

DOI PDF 被引用文献1件
  • Torsten Arndt
    Abteilung Klinische Chemie und Zentrallaboratorium, Baldingerstr
  • Rolf Hackler
    Medizinisches Zentrum für Nervenheilkunde, Funktionsbereich Neurochemie, Rudolf-Bultmannstr. 8
  • Thomas Müller
    Abteilung Nephrologie, Baldingerstr., Philipps-Universität Marburg, D-35033 Marburg, Germany
  • Tilman O Kleine
    Medizinisches Zentrum für Nervenheilkunde, Funktionsbereich Neurochemie, Rudolf-Bultmannstr. 8
  • Axel M Gressner
    Abteilung Klinische Chemie und Zentrallaboratorium, Baldingerstr

書誌事項

公開日
1997-02-01
権利情報
  • https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
DOI
  • 10.1093/clinchem/43.2.344
公開者
Oxford University Press (OUP)

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説明

<jats:title>Abstract</jats:title><jats:p>Serum concentration of carbohydrate-deficient transferrin (cCDT) is used for laboratory diagnosis and follow-up of chronic alcohol abuse. In analyzing by CDTect-RIA (Pharmacia) sera from outpatients with combined pancreas and kidney transplantation and no excessive alcohol consumption, we found above-normal values for cCDT and CDT/transferrin ratios (CDT/Tf) in more than half of the samples. Isoelectric focusing of these samples showed distinct bands of carbohydrate-deficient isotransferrins, supporting the abnormal findings from the CDTect assay. In contrast, diabetics and outpatients who had received only kidney transplants showed normal values for cCDT, CDT/Tf, and isotransferrin patterns. Increased serum Tf, sialidase-producing microorganisms, and immunosuppressive medication were eliminated as causes of these abnormal cCDT and CDT/Tf results. Successful pancreas transplantation leads to hyperinsulinemia and normoglycemia, in contrast to hypoinsulinemia and hyperglycemia in the patients who receive kidney transplants alone. These factors may have pathogenic importance for CDT increase, yielding results falsely interpreted as positive with respect to alcohol abuse in patients with combined pancreas and kidney transplantation.</jats:p>

収録刊行物

  • Clinical Chemistry

    Clinical Chemistry 43 (2), 344-351, 1997-02-01

    Oxford University Press (OUP)

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