Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane
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- Zheng Wang
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Evelyn E. Gurule
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Timothy P. Brennan
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Jeffrey M. Gerold
- Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138;
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- Kyungyoon J. Kwon
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Nina N. Hosmane
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Mithra R. Kumar
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Subul A. Beg
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Adam A. Capoferri
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Stuart C. Ray
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Ya-Chi Ho
- Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536;
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- Alison L. Hill
- Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138;
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- Janet D. Siliciano
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
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- Robert F. Siliciano
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
説明
<jats:title>Significance</jats:title> <jats:p>The HIV-1 latent reservoir cannot be eradicated by antiretroviral therapy (ART). The reservoir is a major barrier to cure. To characterize the mechanisms that contribute to persistence of the latent reservoir, we examined clonally expanded cell populations carrying replication-competent HIV-1 and followed them longitudinally. Expanded clones harboring replication-competent HIV-1 were identified in all study participants, but these clones emerge and wane on a time scale of years. A similar pattern was identified in viruses sampled from residual viremia. The findings suggest that the latent reservoir is likely to be maintained through expansion driven by antigens and cytokines, and that the expansion is balanced with a constant cell loss.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 115 (11), E2575-, 2018-02-26
Proceedings of the National Academy of Sciences