Exercise, Neurotrophins, and Axon Regeneration in the PNS

DOI Web Site 1 Citations
  • Arthur W. English
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia; and
  • Jennifer C. Wilhelm
    Department of Psychology, College of Charleston, Charleston, South Carolina
  • Patricia J. Ward
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia; and

Description

<jats:p>Electrical stimulation and exercise are treatments to enhance recovery from peripheral nerve injuries. Brain-derived neurotrophic factor and androgen receptor signaling are requirements for the effectiveness of these treatments. Increased neuronal activity is adequate to promote regeneration in injured nerves, but the dosing of activity and its relationship to neurotrophins and sex steroid hormones is less clear. Translation of these therapies will require principles associated with their cellular mechanisms.</jats:p>

Journal

  • Physiology

    Physiology 29 (6), 437-445, 2014-11

    American Physiological Society

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