<i>Tmc</i> gene therapy restores auditory function in deaf mice

  • Charles Askew
    Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Cylia Rochat
    Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015 Lausanne, Switzerland.
  • Bifeng Pan
    Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Yukako Asai
    Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Hena Ahmed
    Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Erin Child
    Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Bernard L. Schneider
    Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015 Lausanne, Switzerland.
  • Patrick Aebischer
    Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015 Lausanne, Switzerland.
  • Jeffrey R. Holt
    Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

説明

<jats:p> Injection of AAV vectors that encoded wild-type <jats:italic>Tmc1</jats:italic> or <jats:italic>Tmc2</jats:italic> restores auditory function in mouse models of human deafnesses DFNB7/11 and DFNA36. </jats:p>

収録刊行物

  • Science Translational Medicine

    Science Translational Medicine 7 (295), 295ra108-, 2015-07-08

    American Association for the Advancement of Science (AAAS)

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