Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges
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- Talveen S. Purba
- The Dermatology Centre, Salford Royal NHS Foundation Trust and Institute of Inflammation and Repair University of Manchester Manchester United Kingdom
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- Iain S. Haslam
- The Dermatology Centre, Salford Royal NHS Foundation Trust and Institute of Inflammation and Repair University of Manchester Manchester United Kingdom
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- Enrique Poblet
- Department of Pathology University General Hospital and Murcia University Spain
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- Francisco Jiménez
- Mediteknia Dermatology Clinic Las Palmas Gran Canaria Spain
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- Alberto Gandarillas
- Cell Cycle, Stem Cell Fate and Cancer Laboratory Instituto de Formación e Investigación Marqués de Valdecilla (FMDV‐IFIMAV) Santander Spain. INSERM France
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- Ander Izeta
- Instituto Biodonostia, Hospital Universitario Donostia San Sebastian Spain
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- Ralf Paus
- The Dermatology Centre, Salford Royal NHS Foundation Trust and Institute of Inflammation and Repair University of Manchester Manchester United Kingdom
書誌事項
- 公開日
- 2014-03-25
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/bies.201300166
- 公開者
- Wiley
この論文をさがす
説明
<jats:sec><jats:label/><jats:p>Epithelial hair follicle stem cells (eHFSCs) are required to generate, maintain and renew the continuously cycling hair follicle (HF), supply cells that produce the keratinized hair shaft and aid in the reepithelialization of injured skin. Therefore, their study is biologically and clinically important, from alopecia to carcinogenesis and regenerative medicine. However, human eHFSCs remain ill defined compared to their murine counterparts, and it is unclear which murine eHFSC markers really apply to the human HF. We address this by reviewing current concepts on human eHFSC biology, their immediate progeny and their molecular markers, focusing on Keratin 15 and 19, CD200, CD34, PHLDA1, and EpCAM/Ber‐EP4. After delineating how human eHFSCs may be selectively targeted experimentally, we close by defining as yet unmet key challenges in human eHFSC research. The ultimate goal is to transfer emerging concepts from murine epithelial stem cell biology to human HF physiology and pathology.</jats:p></jats:sec>
収録刊行物
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- BioEssays
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BioEssays 36 (5), 513-525, 2014-03-25
Wiley
