Transfusion-Related Acute Lung Injury (TRALI) and Transfusion-Associated Circulatory Overload (TACO) in Liver Transplantation: A Case Report and Focused Review

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  • Natalie K. Smith
    The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA
  • Sang Kim
    The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA
  • Bryan Hill
    The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA
  • Andrew Goldberg
    The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA
  • Samuel DeMaria
    The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA
  • Jeron Zerillo
    The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA

書誌事項

公開日
2017-10-12
権利情報
  • https://journals.sagepub.com/page/policies/text-and-data-mining-license
DOI
  • 10.1177/1089253217736298
公開者
SAGE Publications

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説明

<jats:p>Liver transplantation (LT) is a complex procedure in a patient with multi-organ system dysfunction and coagulation defects. The surgical procedure involves dissection, major vessel manipulation, and pathophysiologic effects of graft storage and reperfusion. As a result, LT frequently involves significant hemorrhage. Subsequent massive transfusion carries high risk of transfusion-associated complications. Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are the leading causes of transfusion associated mortality. In this case report and focused review, we present data that suggest that patients undergoing liver transplantation may be at higher risk for TRALI and TACO than the general population. Anesthesiologists can play a role in decreasing these risks by increasing recognition and reporting of TRALI and TACO, using point of care testing with thromboelastography to guide and decrease transfusion, and considering alternatives to traditional blood products like solvent/detergent plasma.</jats:p>

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