New insights into basophil biology: initiators, regulators, and effectors of type 2 inflammation
書誌事項
- 公開日
- 2011-01
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1749-6632.2010.05918.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Recent studies indicate that basophils perform essential functions in multiple models of Th2 cytokine‐dependent immunity and inflammation. In addition to their role as late phase effector cells, basophil populations can express MHC class II and costimulatory molecules, migrate into draining lymph nodes, present antigen to naive CD4<jats:sup>+</jats:sup> T cells, and promote Th2 cell differentiation. In this context, basophils have been shown to contribute to the induction and propagation of Th2 cytokine responses following exposure to some helminth parasites or allergens. In this review, we discuss recent studies that provide new insights into basophil development, regulation, and effector function. In addition, we discuss the ability of basophils to act both independently and cooperatively with dendritic cells to support Th2 cytokine‐mediated inflammation.</jats:p>
収録刊行物
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- Annals of the New York Academy of Sciences
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Annals of the New York Academy of Sciences 1217 (1), 166-177, 2011-01
Wiley
