The Role of Multidrug Efflux Pumps in the Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and Other Gram‐Negative Bacteria
書誌事項
- タイトル別名
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- Insights from the Society of Infectious Diseases Pharmacists
- 公開日
- 2003-07
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1592/phco.23.7.916.32722
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Gram‐negative bacteria remain clinically important pathogens in both hospital and community settings. Recent research indicates that efflux pumps play a prominent role in the multidrug resistance of <jats:italic>Pseudomonas aeruginosa</jats:italic> and many other gram‐negative bacteria. Four multidrug efflux pump systems have been well characterized in <jats:italic>P. aeruginosa</jats:italic>: MexA‐MexB‐OprM, MexC‐MexD‐OprJ, MexE‐MexF‐OprN, and MexX‐MexY‐OprM. These efflux pumps have different substrate specificities, and their production and activity can be increased by many factors commonly present in infections (e.g., high inocula of bacteria, low pH, and stationary‐phase growth). Moreover, fluoroquinolone antibiotics can commonly select mutants that constitutively overproduce Mex‐Opr efflux pump systems. Based on most recent studies, the prevalence of efflux pump overproduction in clinical strains of <jats:italic>P. aeruginosa</jats:italic> may range from 14–75%. The best treatment for infections caused by bacteria that overproduce efflux pumps is unknown, but pharmacodynamic optimization of antibiotics and the use of antibiotic combinations that are substrates for different pump systems may represent reasonable strategies until more data are available.</jats:p>
収録刊行物
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- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 23 (7), 916-924, 2003-07
Wiley