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- Elly M. Tanaka
- DFG-Center for Regenerative Therapies Dresden, Technische Universität Dresden, and Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany;,
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説明
<jats:p> Salamander limb regeneration is a classical model of tissue morphogenesis and patterning. Through recent advances in cell labeling and molecular analysis, a more precise, mechanistic understanding of this process has started to emerge. Long-standing questions include to what extent limb regeneration recapitulates the events observed in mammalian limb development and to what extent are adult- or salamander- specific aspects deployed. Historically, researchers studying limb development and limb regeneration have proposed different models of pattern formation. Here we discuss recent data on limb regeneration and limb development to argue that although patterning mechanisms are likely to be similar, cell plasticity and signaling from nerves play regeneration-specific roles. </jats:p>
収録刊行物
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- Annual Review of Cell and Developmental Biology
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Annual Review of Cell and Developmental Biology 27 (1), 409-440, 2011-11-10
Annual Reviews
