Dissecting the role of hyaluronan synthases in the tumor microenvironment

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  • Alberto Passi
    Department of Medicine and Surgery University of Insubria Varese Italy
  • Davide Vigetti
    Department of Medicine and Surgery University of Insubria Varese Italy
  • Simone Buraschi
    Department of Pathology, Anatomy and Cell Biology and the Cancer Cell Biology and Signaling Program Sidney Kimmel Cancer Center Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia PA USA
  • Renato V. Iozzo
    Department of Pathology, Anatomy and Cell Biology and the Cancer Cell Biology and Signaling Program Sidney Kimmel Cancer Center Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia PA USA

書誌事項

公開日
2019-04-22
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/febs.14847
公開者
Wiley

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説明

<jats:p>The tumor microenvironment is becoming a crucial factor in determining the aggressiveness of neoplastic cells. The glycosaminoglycan hyaluronan is one of the principal constituents of both the tumor stroma and the cancer cell surfaces, and its accumulation can dramatically influence patient survival. Hyaluronan functions are dictated by its ability to interact with several signaling receptors that often activate pro‐angiogenic and pro‐tumorigenic intracellular pathways. Although hyaluronan is a linear, non‐sulfated polysaccharide, and thus lacks the ability of the other sulfated glycosaminoglycans to bind and modulate growth factors, it compensates for this by the ability to form hyaluronan fragments characterized by a remarkable variability in length. Here, we will focus on the role of both high and low molecular weight hyaluronan in controlling the hallmarks of cancer cells, including cell proliferation, migration, metabolism, inflammation, and angiogenesis. We will critically assess the multilayered regulation of <jats:styled-content style="fixed-case">HAS</jats:styled-content>2, the most critical hyaluronan synthase, and its role in cancer growth, metabolism, and therapy.</jats:p>

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