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- Christine R. Beck
- Department of Human Genetics,
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- José Luis Garcia-Perez
- Andalusian Stem Cell Bank, Center for Biomedical Research, University of Granada, Armilla, Granada 18100, Spain
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- Richard M. Badge
- Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
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- John V. Moran
- Department of Human Genetics,
書誌事項
- 公開日
- 2011-09-22
- DOI
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- 10.1146/annurev-genom-082509-141802
- 公開者
- Annual Reviews
この論文をさがす
説明
<jats:p> The completion of the human genome reference sequence ushered in a new era for the study and discovery of human transposable elements. It now is undeniable that transposable elements, historically dismissed as junk DNA, have had an instrumental role in sculpting the structure and function of our genomes. In particular, long interspersed element-1 (LINE-1 or L1) and short interspersed elements (SINEs) continue to affect our genome, and their movement can lead to sporadic cases of disease. Here, we briefly review the types of transposable elements present in the human genome and their mechanisms of mobility. We next highlight how advances in DNA sequencing and genomic technologies have enabled the discovery of novel retrotransposons in individual genomes. Finally, we discuss how L1-mediated retrotransposition events impact human genomes. </jats:p>
収録刊行物
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- Annual Review of Genomics and Human Genetics
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Annual Review of Genomics and Human Genetics 12 (1), 187-215, 2011-09-22
Annual Reviews
