ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment
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- Veronica Gatti
- Department of Experimental Medicine TOR University of Rome, Tor Vergata Italy
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- Claudia Fierro
- Department of Experimental Medicine TOR University of Rome, Tor Vergata Italy
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- Margherita Annicchiarico‐Petruzzelli
- Istituto Dermopatico dell'Immacolata IDI‐IRCCS Rome Italy
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- Gerry Melino
- Department of Experimental Medicine TOR University of Rome, Tor Vergata Italy
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- Angelo Peschiaroli
- National Research Council of Italy Institute of Translational Pharmacology Rome Italy
抄録
<jats:p>Squamous cell carcinoma (<jats:styled-content style="fixed-case">SCC</jats:styled-content>) is a treatment‐refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecular features commonly observed in <jats:styled-content style="fixed-case">SCC</jats:styled-content> of distinct origins. Some of these genetic events culminate in fostering the activity of ΔNp63, a potent oncogene which exerts its pro‐tumourigenic effects by regulating specific transcriptional programmes to sustain malignant cell proliferation and survival. In this review, we will describe the genetic and epigenetic determinants underlying ΔNp63 oncogenic activities in <jats:styled-content style="fixed-case">SCC</jats:styled-content>, and discuss some relevant transcriptional effectors of ΔNp63, emphasizing their impact in modulating the crosstalk between tumour cells and tumour microenvironment (<jats:styled-content style="fixed-case">TME</jats:styled-content>).</jats:p>
収録刊行物
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- Molecular Oncology
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Molecular Oncology 13 (5), 981-1001, 2019-03-22
Wiley