Glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials
Description
<jats:sec><jats:title>Objective</jats:title><jats:p>The role of glucagon-like peptide-1 (GLP-1) receptor agonists in the treatment of type 2 diabetes is debated; many recent trials, which were not included in previous meta-analyses, could add relevant information.</jats:p></jats:sec><jats:sec><jats:title>Design and methods</jats:title><jats:p>All available randomized controlled trials (RCTs), either published or unpublished, performed in type 2 diabetic patients with GLP-1 receptor agonists (exenatide and liraglutide), with a duration>12 weeks were meta-analysed for HbA1c, body mass index, hypoglycaemia and other adverse events.</jats:p></jats:sec><jats:sec><jats:title>Results and conclusions</jats:title><jats:p>A total of 21 RCTs (six of which unpublished), enrolling 5429 and 3053 patients (with GLP-1 receptor agonists and active comparator or placebo respectively), was retrieved and included in the analysis. GLP-1 receptor agonists determine a significant improvement of HbA1c in comparison with placebo (−1.0 (−1.1, −0.8),<jats:italic>P</jats:italic><0.001), with a low risk of hypoglycaemia. There is no evidence of increased cardiovascular risk with the use of GLP-1 receptor agonists. GLP-1 receptor agonists, which induce weight loss, are associated with gastrointestinal side effects. GLP-1 receptor agonists are effective in reducing HbA1c and postprandial glucose. In patients failing to sulphonylureas and/or metformin, GLP-1 receptor agonists are similarly effective as insulin. Available data suggest that the efficacy and tolerability of the novel agent, liraglutide, which is adequate for once-a-day administration, are comparable with those of exenatide bis in die.</jats:p></jats:sec>
Journal
-
- European Journal of Endocrinology
-
European Journal of Endocrinology 160 (6), 909-917, 2009-06
Oxford University Press (OUP)
- Tweet
Details 詳細情報について
-
- CRID
- 1363670320021544192
-
- ISSN
- 1479683X
- 08044643
-
- Data Source
-
- Crossref