Cellular dynamics in the muscle satellite cell niche
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- C Florian Bentzinger
- Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute 501 Smyth Road Ottawa Ontario K1H 8L6 Canada
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- Yu Xin Wang
- Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute 501 Smyth Road Ottawa Ontario K1H 8L6 Canada
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- Nicolas A Dumont
- Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute 501 Smyth Road Ottawa Ontario K1H 8L6 Canada
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- Michael A Rudnicki
- Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute 501 Smyth Road Ottawa Ontario K1H 8L6 Canada
書誌事項
- 公開日
- 2013-11-15
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1038/embor.2013.182
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
<jats:p>Satellite cells, the quintessential skeletal muscle stem cells, reside in a specialized local environment whose anatomy changes dynamically during tissue regeneration. The plasticity of this niche is attributable to regulation by the stem cells themselves and to a multitude of functionally diverse cell types. In particular, immune cells, fibrogenic cells, vessel‐associated cells and committed and differentiated cells of the myogenic lineage have emerged as important constituents of the satellite cell niche. Here, we discuss the cellular dynamics during muscle regeneration and how disease can lead to perturbation of these mechanisms. To define the role of cellular components in the muscle stem cell niche is imperative for the development of cell‐based therapies, as well as to better understand the pathobiology of degenerative conditions of the skeletal musculature.</jats:p>
収録刊行物
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- EMBO reports
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EMBO reports 14 (12), 1062-1072, 2013-11-15
Springer Science and Business Media LLC
