Lipoprotein Phospholipase A2 and Cerebral Microbleeds in the Framingham Heart Study
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- José Rafael Romero
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Sarah R. Preis
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Alexa S. Beiser
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Charles DeCarli
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Dong Young Lee
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Anand Viswanathan
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Emelia J. Benjamin
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Joao Fontes
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Rhoda Au
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Aleksandra Pikula
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Jimmy Wang
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Carlos S. Kase
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Philip A. Wolf
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Michael C. Irrizary
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
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- Sudha Seshadri
- From the Department of Neurology (J.R.R., A.S.B., R.A., A.P., C.S.K., P.A.W., S.S.), Sections of Preventive Medicine (E.J.B.), and Cardiology (E.J.B., J.F.), and Department of Radiology (J.W.), School of Medicine and the Department of Biostatistics (S.R.P., A.S.B.), School of Public Health at Boston University, Boston, MA; Department of Neurology University of California-Davis, Davis, California (C.D.); Department of Neurology, Harvard Medical School, Boston, MA (A.V.); WW Epidemiology, Research and...
書誌事項
- 公開日
- 2012-11
- DOI
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- 10.1161/strokeaha.112.656744
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Cerebral microbleeds (CMB) attributable to cerebral amyloid angiopathy generally occur in lobar regions, whereas those attributable to hypertensive vasculopathy are deep. Inflammation may be an underlying mechanism for CMB, with varying associations according to CMB location. Lipoprotein phospholipase-A2 (Lp-PLA2) is a circulating enzyme marker of vascular inflammation associated with risk of ischemic stroke and dementia. We hypothesized that higher Lp-PLA2 levels would be related to higher prevalence of CMB, with possible regional specificity.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p> Framingham Offspring participants aged 65 years or older with available Lp-PLA2 measures and brain magnetic resonance imaging were included. Logistic regression models were used to relate Lp-PLA2 activity and mass to presence of CMB, adjusted for age, sex, medication use (aspirin, anticoagulants, and statins), systolic blood pressure, <jats:italic>APOE</jats:italic> , current smoking, and diabetes. </jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> Eight-hundred nineteen participants (mean age, 73 years; 53% women) were included; 106 (13%) had CMB, 82 (10%) were lobar, and 27 (3%) were deep. We did not observe significant associations of CMB and LpPLA2 measures in multivariable adjusted analyses. However, there was a significant interaction between <jats:italic>APOE</jats:italic> genotype and Lp-PLA2 activity in their relation to presence of deep CMB ( <jats:italic>P</jats:italic> interaction=0.01). Among persons with <jats:italic>APOE</jats:italic> ɛ <jats:italic>3</jats:italic> /ɛ <jats:italic>3</jats:italic> , the odds ratio for deep CMB was 0.95 (confidence interval, 0.59-1.53; <jats:italic>P</jats:italic> =0.83), whereas among those with at least 1 ɛ <jats:italic>2</jats:italic> or ɛ <jats:italic>4</jats:italic> allele, odds ratio was 3.46 (confidence interval, 1.43-8.36; <jats:italic>P</jats:italic> =0.006). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p> In our community-based sample of older adults, there was no significant association of Lp-PLA2 with total or lobar CMB. The association of higher levels of Lp-PLA2 activity with deep CMB among those with at least 1 <jats:italic>APOE</jats:italic> ɛ <jats:italic>2</jats:italic> or ɛ <jats:italic>4</jats:italic> allele merits replication. </jats:p> </jats:sec>
収録刊行物
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- Stroke
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Stroke 43 (11), 3091-3094, 2012-11
Ovid Technologies (Wolters Kluwer Health)
