Localization of a Novel v-<i>erb</i>B-Related Gene, c-<i>erb</i>B-2, on Human Chromosome 17 and Its Amplification in a Gastric Cancer Cell Line
-
- Shin-Ichi Fukushige
- Institute for Moleciular and Celluilar Biology, Osaka University, Suiita, Osaka 565, Japan
-
- Ken-Ichi Matsubara
- Institute for Moleciular and Celluilar Biology, Osaka University, Suiita, Osaka 565, Japan
-
- Michihiro Yoshida
- Chromosome Research Unit, Hokkaido University, N. 10-W.8, Sapporo 060, Japan
-
- Motomichi Sasaki
- Chromosome Research Unit, Hokkaido University, N. 10-W.8, Sapporo 060, Japan
-
- Toshimitsu Suzuki
- School of Medicine, Niigata University, Niigata 951, Japan
-
- Kentaro Semba
- The Institiute of Medical Science, The University of Tokyo, Minato-ku Tokyo 108, Japan
-
- Kumao Toyoshima
- The Institiute of Medical Science, The University of Tokyo, Minato-ku Tokyo 108, Japan
-
- Tadashi Yamamoto
- The Institiute of Medical Science, The University of Tokyo, Minato-ku Tokyo 108, Japan
書誌事項
- 公開日
- 1986-03-01
- 権利情報
-
- https://journals.asm.org/non-commercial-tdm-license
- DOI
-
- 10.1128/mcb.6.3.955-958.1986
- 10.1128/mcb.6.3.955
- 公開者
- Informa UK Limited
この論文をさがす
説明
<jats:p>The c-erbB-2 gene is a v-erbB-related proto-oncogene which is distinct from the gene encoding the epidermal growth factor receptor. By using two independent methods, hybridization of both sorted chromosomes and metaphase spreads with cloned c-erbB-2 DNA, we mapped the c-erbB-2 locus on human chromosome 17 at q21, a specific breakpoint observed in a translocation associated with acute promyelocytic leukemia. Furthermore, we observed amplification and elevated expression of the c-erbB-2 gene in the MKN-7 gastric cancer cell line. These data suggest possible involvement of the c-erbB-2 gene in human cancer.</jats:p>
収録刊行物
-
- Molecular and Cellular Biology
-
Molecular and Cellular Biology 6 (3), 955-958, 1986-03-01
Informa UK Limited
