Age-Dependent Diarrhea Induced by a Rotaviral Nonstructural Glycoprotein

DOI Web Site 被引用文献10件
  • Judith M. Ball
    J. M. Ball, P. Tian, C. Q.-Y. Zeng, M. K. Estes, Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
  • Peng Tian
    J. M. Ball, P. Tian, C. Q.-Y. Zeng, M. K. Estes, Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
  • Carl Q.-Y. Zeng
    J. M. Ball, P. Tian, C. Q.-Y. Zeng, M. K. Estes, Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
  • Andrew P. Morris
    A. P. Morris, Department of Integrative Biology, University of Texas Health Science Center, Houston, TX 77030, USA.
  • Mary K. Estes
    J. M. Ball, P. Tian, C. Q.-Y. Zeng, M. K. Estes, Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

書誌事項

公開日
1996-04-05
DOI
  • 10.1126/science.272.5258.101
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>The rotavirus nonstructural glycoprotein NSP4 is an intracellular receptor that mediates the acquisition of a transient membrane envelope as subviral particles bud into the endoplasmic reticulum. NSP4 also causes an increase in intracellular calcium in insect cells. Purified NSP4 or a peptide corresponding to NSP4 residues 114 to 135 induced diarrhea in young (6 to 10 days old) CD1 mice. This disease response was age-dependent, dose-dependent, and specific. Electrophysiologic data from intestinal mucosa showed that the NSP4 114–135 peptide potentiates chloride secretion by a calcium-dependent signaling pathway. Diarrhea is induced when NSP4, acting as a viral enterotoxin, triggers a signal transduction pathway.</jats:p>

収録刊行物

  • Science

    Science 272 (5258), 101-104, 1996-04-05

    American Association for the Advancement of Science (AAAS)

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