Lymphotoxin-Mediated Regulation of γδ Cell Differentiation by αß T Cell Progenitors
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- Bruno Silva-Santos
- Peter Gorer Department of Immunobiology, Guy's King's St. Thomas' Medical School, King's College, Guy's Hospital, London SE1 9RT, UK.
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- Daniel J. Pennington
- Peter Gorer Department of Immunobiology, Guy's King's St. Thomas' Medical School, King's College, Guy's Hospital, London SE1 9RT, UK.
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- Adrian C. Hayday
- Peter Gorer Department of Immunobiology, Guy's King's St. Thomas' Medical School, King's College, Guy's Hospital, London SE1 9RT, UK.
書誌事項
- 公開日
- 2005-02-11
- DOI
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- 10.1126/science.1103978
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p> The thymus gives rise to two T cell lineages, αβ and γδ, that are thought to develop independently of one another. Hence, double positive (DP) thymocytes expressing CD4 and CD8 coreceptors are usually viewed simply as progenitors of CD4 <jats:sup>+</jats:sup> and CD8 <jats:sup>+</jats:sup> αβ T cells. Instead we report that DP cells regulate the differentiation of early thymocyte progenitors and γδ cells, by a mechanism dependent on the transcription factor RORgt, and the lymphotoxin (LT) β receptor (LTβR). This finding provokes a revised view of the thymus, in which lymphoid tissue induction-type processes coordinate the developmental and functional integration of the two T cell lineages. </jats:p>
収録刊行物
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- Science
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Science 307 (5711), 925-928, 2005-02-11
American Association for the Advancement of Science (AAAS)
