A new approach to gephyrotoxin

書誌事項

公開日
1983-01
権利情報
  • https://www.elsevier.com/tdm/userlicense/1.0/
DOI
  • 10.1016/s0040-4039(00)88049-1
公開者
Elsevier BV

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説明

Abstract CsF induced 1,4-elimination of ammonium bromide 1a and the subsequent intramolecular cyclization of the resulting o-quinone methide N-alkenylimine 2a afforded benzo[e]-indolizidine 4a as a 4∼5 : 1 stereoisomeric mixture. Hydrogenation of 4a with 5% Rh on alumina gave tricyclic enaminoketones 5i and 5ii, of which stereoselective elaboration to gephyrotoxin 8 has already been established.

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