Oral and Extraoral Plasmablastic Lymphoma

DOI PDF 被引用文献3件
  • Damien Hansra
    1Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL
  • Naomi Montague
    3Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL
  • Alexandra Stefanovic
    1Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL
  • Ikechukwu Akunyili
    1Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL
  • Arash Harzand
    1Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL
  • Yasodha Natkunam
    4Department of Pathology, Stanford University School of Medicine, Stanford, CA
  • Margarita de la Ossa
    3Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL
  • Gerald E. Byrne
    3Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL
  • Izidore S. Lossos
    1Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL

書誌事項

公開日
2010-11-01
DOI
  • 10.1309/ajcpjh6keusecqlu
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We reviewed clinical, morphologic, and immunophenotypic features of 13 cases of PBL to determine whether these different subtypes represent distinct morphologic and clinical entities. Two distinct subtypes of PBL were identified and classified as oral and extraoral PBL. The oral PBLs were strongly associated with HIV infection and commonly demonstrated plasmablastic morphologic features without plasmacytic differentiation. Extraoral PBLs tended to occur in patients with underlying non–HIV-related immunosuppression and universally demonstrated plasmacytic differentiation. The patients with oral PBL demonstrated better overall survival compared with patients with extraoral PBL (P = .02). Our findings suggest that PBL with oral and extraoral manifestation represent 2 distinct clinicopathologic entities.</jats:p>

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