Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug
書誌事項
- 公開日
- 2006-12
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
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- 10.1016/j.bmcl.2006.08.115
- 公開者
- Elsevier BV
この論文をさがす
説明
Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.
収録刊行物
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- Bioorganic & Medicinal Chemistry Letters
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Bioorganic & Medicinal Chemistry Letters 16 (23), 5982-5987, 2006-12
Elsevier BV