The Cell Activation Phenomena in the Cold Atmospheric Plasma Cancer Treatment
説明
<jats:title>Abstract</jats:title><jats:p>Cold Atmospheric Plasma (CAP) is an ionized gas with a near room temperature. CAP is a controllable source for reactive species, neutral particles, electromagnetic field and UV radiation. CAP showed the promising application in cancer treatment through the demonstration <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>. In this study, we first demonstrate the existence of an activation state on the CAP-treated cancer cells, which drastically decreases the threshold of cell vulnerability to the cytotoxicity of the CAP-originated reactive species such as H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and NO<jats:sub>2</jats:sub><jats:sup>−</jats:sup>. The cytotoxicity of CAP treatment is still dependent on the CAP-originated reactive species. The activation state of cancer cells will not cause noticeable cytotoxicity. This activation is an instantaneous process, started even just 2 s after the CAP treatment begins. The noticeable activation on the cancer cells starts 10–20 s during the CAP treatment. In contrast, the de-sensitization of activation takes 5 hours after the CAP treatment. The CAP-based cell activation explains the mechanism by which direct CAP treatment causes a much stronger cytotoxicity over the cancer cells compared with an indirect CAP treatment do, which is a key to understand what the effect of CAP on cancer cells.</jats:p>
収録刊行物
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- Scientific Reports
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Scientific Reports 8 (1), 15418-, 2018-10-18
Springer Science and Business Media LLC
