Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection
Abstract
<jats:p>The problem of the emergence and survival of self-replicating molecules in origin-of-life scenarios is plagued by the error catastrophe, which is usually escaped by considering effects of compartmentalization, as in the stochastic corrector model. By addressing the problem in a simple system composed of a self-replicating molecule (a replicase) and a parasite molecule that needs the replicase for copying itself, we show that transient (rather than permanent) compartmentalization is sufficient to the task. We also exhibit a regime in which the concentrations of the two kinds of molecules undergo sustained oscillations. Our model should be relevant not only for origin-of-life scenarios but also for describing directed evolution experiments, which increasingly rely on transient compartmentalization with pooling and natural selection.</jats:p>
Journal
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- Life
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Life 9 (4), 78-, 2019-10-03
MDPI AG
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Details 詳細情報について
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- CRID
- 1363670320642250112
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- ISSN
- 20751729
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- Data Source
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- Crossref