The Acute Effects of Transthoracic Cryoablation on Normal Lung Evaluated in a Porcine Model
書誌事項
- 公開日
- 2005-01
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
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- 10.1016/j.athoracsur.2003.09.082
- 公開者
- Elsevier BV
この論文をさがす
説明
Percutaneous transthoracic cryoablation of lung parenchymal tumors offers a potentially less invasive alternative to thoracoscopic tumor resection. In the present study, we investigated the feasibility of transthoracic cryoprobe insertion into the lung parenchyma.Cryoablation was performed in porcine lung through a thoracotomy. A 2-mm diameter cryoprobe was inserted to a depth of 3 cm from the pleura. Cryoablation was performed as one or two cycles of 15-minute freeze followed by 5-minute thaw. Bleeding time and amount, and air leakage pressure from the insertion site was measured and compared between cycles.The bleeding time and amount significantly increased, and air leakage pressure significantly decreased with two cycles of cryoablation compared with one cycle. Histologically, the primary finding in the cryolesion was localized pulmonary hemorrhage.Bleeding time, bleeding amount, and air leakage from the insertion site after two cycles (453 +/- 202 s, 1.3 +/- 0.6 g, and 28 +/- 12 cm H2O, respectively) were considered unlikely to cause acute serious complications. Although long-term studies are needed, the present study provides support for transthoracic cryoablation.
収録刊行物
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- The Annals of Thoracic Surgery
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The Annals of Thoracic Surgery 79 (1), 318-322, 2005-01
Elsevier BV