An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

DOI Web Site 被引用文献168件
  • G. Kuo
    Chiron Corporation, Emeryville, CA 94608.
  • Q.-L. Choo
    Chiron Corporation, Emeryville, CA 94608.
  • H.J. Alter
    Centers for Disease Control, 1600 Clifton Road NE, Atlanta, GA 30333.
  • G.L. Gitnick
    Department of Transfusion Medicine Clinical Center, National Institutes of Health, Bethesda, MD 20205.
  • A.G. Redeker
    Department of Medicine, University of Southern California, Liver Unit, Rancho Los Amigos Medical Center, Downev, CA 90242.
  • R.H. Purcell
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20205.
  • T. Miyamura
    National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan.
  • J.L. Dienstag
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114.
  • M.J. Alter
    Department of Transfusion Medicine Clinical Center, National Institutes of Health, Bethesda, MD 20205.
  • C.E. Stevens
    Laboratory of Epidemiology, New York Blood Center New York 10021.
  • G. E. Tegtmeier
    Community Blood Center of Greater Kansas City, Kansas City, MO 64111.
  • F. Bonino
    Divisione di Gastroenterologia, Ospedale Maggiore di S. Giovanni Battista, Molinette, Torino, Italy.
  • M. Colombo
    Instituto di Medicina Interna, Clinica Medica 3, Universita di Milano, Via Pace, 9, 20122, Milan, Italy.
  • W.-S. Lee
    Chiron Corporation, Emeryville, CA 94608.
  • C. Kuo
    Chiron Corporation, Emeryville, CA 94608.
  • K. Berger
    Chiron Corporation, Emeryville, CA 94608.
  • J. R. Shuster
    Chiron Corporation, Emeryville, CA 94608.
  • L. R. Overby
    Chiron Corporation, Emeryville, CA 94608.
  • D. W. Bradley
    Centers for Disease Control, 1600 Clifton Road NE, Atlanta, GA 30333.
  • M. Houghton
    Chiron Corporation, Emeryville, CA 94608.

書誌事項

公開日
1989-04-21
DOI
  • 10.1126/science.2496467
公開者
American Association for the Advancement of Science (AAAS)

この論文をさがす

説明

<jats:p>A specific assay has been developed for a blood-borne non-A, non-B hepatitis (NANBH) virus in which a polypeptide synthesized in recombinant yeast clones of the hepatitis C virus (HCV) is used to capture circulating viral antibodies. HCV antibodies were detected in six of seven human sera that were shown previously to transmit NANBH to chimpanzees. Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses. About 80 percent of chronic, post-transfusion NANBH (PT-NANBH) patients from Italy and Japan had circulating HCV antibody; a much lower frequency (15 percent) was observed in acute, resolving infections. In addition, 58 percent of NANBH patients from the United States with no identifiable source of parenteral exposure to the virus were also positive for HCV antibody. These data indicate that HCV is a major cause of NANBH throughout the world.</jats:p>

収録刊行物

  • Science

    Science 244 (4902), 362-364, 1989-04-21

    American Association for the Advancement of Science (AAAS)

被引用文献 (168)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ