Physical Map of Human 6p21.2–6p21.3: Region Flanking the Centromeric End of the Major Histocompatibility Complex

Nicos Tripodis, Ruth Mason, Sean J. Humphray, Angela F. Davies, Jethro A. Herberg, John Trowsdale, Dean Nizetic, Gabriele Senger, Jiannis Ragoussis

doi:10.1101/gr.8.6.631

<jats:p>We have physically mapped and cloned a 2.5-Mb chromosomal segment flanking the centromeric end of the major histocompatibility complex (MHC). We characterized in detail 27 YACs, 144 cosmids, 51 PACs, and 5 BACs, which will facilitate the complete genomic sequencing of this region of chromosome 6. The contig contains the genes encoding CSBP, p21, HSU09564 serine kinase, ZNF76, <jats:italic>TCP-11,</jats:italic> RPS10, HMGI(Y), BAK, and the human homolog of Tctex-7 (HSET). The <jats:italic>GLO1</jats:italic> gene was mapped further centromeric in the 6p21.2–6p21.1 region toward<jats:italic>TCTE-1.</jats:italic> The gene order of the <jats:italic>GLO1–HMGI(Y)</jats:italic> segment in respect to the centromere is similar to the gene order in the mouse<jats:italic>t</jats:italic>-chromosome distal inversion, indicating that there is conservation in gene content but not gene order between humans and mice in this region. The close linkage of the <jats:italic>BAK</jats:italic> and <jats:italic>CSBP</jats:italic>genes to the MHC is of interest because of their possible involvement in autoimmune disease.</jats:p>

Physical Map of Human 6p21.2–6p21.3: Region Flanking the Centromeric End of the Major Histocompatibility Complex

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