The Inducible Costimulator (ICOS) Is Critical for the Development of Human T <sub>H</sub> 17 Cells

DOI Web Site 6 Citations
  • Chrystal M. Paulos
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Carmine Carpenito
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Gabriela Plesa
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Megan M. Suhoski
    Stanford University School of Medicine, Palo Alto, CA 94305–2296, USA.
  • Angel Varela-Rohena
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Tatiana N. Golovina
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Richard G. Carroll
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • James L. Riley
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Carl H. June
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Description

<jats:p> The inducible costimulator ICOS is critical for the differentiation and expansion of human T <jats:sub>H</jats:sub> 17 cells and promotes the antitumor capacity of these cells. </jats:p>

Journal

  • Science Translational Medicine

    Science Translational Medicine 2 (55), 55ra78-, 2010-10-27

    American Association for the Advancement of Science (AAAS)

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