The Radioprotective Effects of Bu-Zhong-Yi-Qi-Tang: A Prescription of Traditional Chinese Medicine
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- Sung-Ho Kim
- Department of Anatomy, College of Veterinary Medicine, Chonnam National University, Puk-Ku, Kwangju, South Korea
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- Song-Eun Lee
- Department of Anatomy, College of Veterinary Medicine, Chonnam National University, Puk-Ku, Kwangju, South Korea
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- Heon Oh
- Department of Anatomy, College of Veterinary Medicine, Chonnam National University, Puk-Ku, Kwangju, South Korea
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- Se-Ra Kim
- Department of Anatomy, College of Veterinary Medicine, Chonnam National University, Puk-Ku, Kwangju, South Korea
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- Sung-Tae Yee
- Department of Biology, College of Natural Science, Sunchon National University, Sunchon, South Korea
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- Young-Beob Yu
- Radiation Food Science and Biotechnology Team, Korea Atomic Energy Research Institute, P.O. Box 105, Yusong, Taejon 305-600, South Korea
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- Myung-Woo Byun
- Radiation Food Science and Biotechnology Team, Korea Atomic Energy Research Institute, P.O. Box 105, Yusong, Taejon 305-600, South Korea
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- Sung-Kee Jo
- Radiation Food Science and Biotechnology Team, Korea Atomic Energy Research Institute, P.O. Box 105, Yusong, Taejon 305-600, South Korea
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<jats:p> We evaluated the effect of Bu-Zhong-Yi-Qi-Tang, a prescription of traditional Oriental medicine, and its major ingredients on protection of the intestine and hematopoietic organs against radiation damage in this study. The jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in mice irradiated with high and low doses of γ-rays. Bu-Zhong-Yi-Qi-Tang administration before irradiation protected the jejunal crypts (p < 0.0001), increased the formation of the endogenous spleen colony (p < 0.05) and reduced the frequency of radiation-induced apoptosis (p < 0.05). In experiments on the effects of the individual ingredient of Bu-Zhong-Yi-Qi-Tang, Rensan (Radix Ginseng), Danggui (Radix Angelicae gigantis), Shengma (Rhizoma Cimicifugae) and Chaihu (Radix Bupleuri) might have major radioprotective effects, and each might have different degrees of effect on these three endpoints. These results indicated that Bu-Zhong-Yi-Qi-Tang might be a better agent than any one of its ingredients to satisfy all three endpoints. Although the mechanisms of this inhibitory effect remain to be elucidated, these results indicated that Bu-Zhong-Yi-Qi-Tang might be a useful radioprotector, especially since it is a relatively non-toxic natural product. Further studies are needed to better characterize the protective nature of Bu-Zhong-Yi-Qi-Tang extract and its ingredients. </jats:p>
収録刊行物
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- The American Journal of Chinese Medicine
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The American Journal of Chinese Medicine 30 (01), 127-137, 2002-01
World Scientific Pub Co Pte Lt
