Fetal γ-globin genes are regulated by the BGLT3 long noncoding RNA locus

DOI PDF 2 Citations
  • Maria Soledad Ivaldi
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; and
  • Luis Francisco Diaz
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; and
  • Lyubomira Chakalova
    Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom
  • Jongjoo Lee
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; and
  • Ivan Krivega
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; and
  • Ann Dean
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; and

Description

<jats:title>Key Points</jats:title> <jats:p>BGLT3 is a developmental stage-specific lncRNA encoded downstream of HBG1 that positively regulates γ-globin genes. BGLT3 locus and transcript have distinct functions in looping and mediator interaction to increase γ-globin transcription.</jats:p>

Journal

  • Blood

    Blood 132 (18), 1963-1973, 2018-11-01

    American Society of Hematology

Citations (2)*help

See more

Details 詳細情報について

Report a problem

Back to top